The nucleotide sequence of bovine MHC class II DQB and DRB genes
نویسندگان
چکیده
منابع مشابه
Sequence analysis of the MHC class II DRB alleles in Alpine chamois (Rupicapra r. rupicapra).
This study characterises the expressed MHC class II DRB gene and its genetic variation in exon 2 among 59 Alpine chamois (Rupicapra r. rupicapra) from several locations in the Eastern Alps plus one population in the Western Alps. The expressed DRB gene contains all the expected characteristics including all of the conserved residues found in other mammalian species. The isolated expressed DRB g...
متن کاملContrasting patterns of selection acting on MHC class I and class II DRB genes in the Alpine marmot (Marmota marmota).
The major histocompatibility complex (MHC) genes code for proteins that play a critical role in the immune system response. The MHC genes are among the most polymorphic genes in vertebrates, presumably due to balancing selection. The two MHC classes appear to differ in the rate of evolution, but the reasons for this variation are not well understood. Here, we investigate the level of polymorphi...
متن کاملAllelic diversity of the MHC class II DRB genes in brown bears (Ursus arctos) and a comparison of DRB sequences within the family Ursidae.
The allelic diversity of the DRB locus in major histocompatibility complex (MHC) genes was analyzed in the brown bear (Ursus arctos) from the Hokkaido Island of Japan, Siberia, and Kodiak of Alaska. Nineteen alleles of the DRB exon 2 were identified from a total of 38 individuals of U. arctos and were highly polymorphic. Comparisons of non-synonymous and synonymous substitutions in the antigen-...
متن کاملGenetic characterization of MHC class II DQB exon 2 variants in gayal (Bos frontalis)
In the present study, exon 2 of major histocompatibility complex (MHC) class II DQB gene from 39 gayals (Bos frontalis) was isolated, characterized and compared with previously reported patterns for other bovidae. It was revealed by sequence analyses that there are 36 DQB exon 2 variants among 39 gayals. These variants exhibited a high degree of nucleotide and amino acid substitutions with most...
متن کاملAssociations of HLA-DRB and -DQB genes with two and five year outcome in rheumatoid arthritis.
OBJECTIVE To evaluate the clinical usefulness of genomic HLA typing during the first five years of established rheumatoid arthritis (RA). METHODS The HLA-DRB and -DQB alleles were determined by restriction length polymorphisms and polymerase chain reaction amplification with sequence specific primers in 99 Swedish patients with RA. Clinical features after two and five years disease duration w...
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ژورنال
عنوان ژورنال: Immunogenetics
سال: 1993
ISSN: 0093-7711,1432-1211
DOI: 10.1007/bf00187464